Senior Scientist (Gene Editing), LNP platform Responsibilities： 1. CRISPR/Cas9 editing system development • Design, develop, screen, and optimize CRISPR/Cas9 genome editing systems. • Design and screen sgRNAs and optimize editing activity. • Develop efficient and specific CRISPR/Cas9 editing strategies for different genomic targets. • Select appropriate Cas9 systems and editing strategies according to specific applications. • Assist in establishing assays for evaluating CRISPR/Cas9 editing efficiency. • Identify and optimize critical factors affecting editing efficiency and specificity. 2. Knock-in Platform Development. • Contribute to the development of CRISPR/Cas9-mediated precision knock-in (KI) technologies. • Design and optimize different types of DNA donors. • Investigate and develop different KI mechanisms and strategies, including but not limited to HDR-mediated KI and NHEJ/HITI-mediated KI. • Explore other DNA donor-mediated KI strategies. • Optimize donor architecture, donor length, homology arms, and target site design. • Investigate the impact of sgRNA, Cas9, donor design, and delivery strategies on KI efficiency. • Support the establishment of screening and quantitative analytical methods for different KI strategies. • Optimize key KI parameters, including KI efficiency, precision, productivity, and specificity. • Support the establishment of a versatile KI platform applicable to different genomic targets and tissue/cell types. Qualifications: 1. PhD degree, preferably graduating in 2026 or recently graduated, in Biology, Molecular Biology, Biochemistry, Bioengineering, Pharmaceutical Sciences, Pharmacology, Gene Therapy, Genome Editing, or a related field. 2. Strong research experience in CRISPR/Cas-based genome editing during PhD training.Solid understanding of CRISPR/Cas9 mechanisms and genome editing technologies. 3. Research experience in at least one of the following areas: • CRISPR/Cas9 • Genome editing • Knock-in / Knock-out • HDR • NHEJ/HITI • DNA donor design • sgRNA design and screening 4. Hands-on experience in knock-in research is strongly preferred, particularly experience in DNA donor design and KI optimization. 5. Familiarity with genome editing analytical methods, including PCR, qPCR/ddPCR, and Sanger sequencing.Strong experimental design, data analysis, and scientific problem-solving skills. 6. Ability to conduct independent research and rapidly learn emerging genome editing and delivery technologies. 7. Strong English scientific literature reading and technical writing skills.