General Description: Downstream process development is a critical function of biologics CMC activities. The goal of downstream process is to develop a set of purification procedures, which can capture, purify targeted drug API from cell culture broth and finally get drug substance. The purification procedure will utilize various bioseperation technology including different chromatography, membrance seperation, UF/DF and some specific skills, such as viral clearance. The process development work also involves scale up, tech transfer to commerical and support GMP manufacturing. It will offer knowledge and understanding of large molecule CMC work, Biochemical Engineering, GMP manufacturing, life cycle of drug and other speical skill, e.g. project management, etc. Job Description (including but not limited to)： 1) Support early-stage and late phase biological product development. Responsible for antibody purification process development and ADC process development, tox material preparation, tech transfer, downstream process optimization and characterization. 2) As function representative, working closely with stakeholders (technical development functions, Research, CMC, Quality, MST/manufacture, Reg CMC, clinical operation, etc.) to advance technical development of newly NMEs according to aligned development timeline. Enable IND/BLA submission per aligned CMC timeline. 3) Key contributor to relevant CMC sections in IND/BLA submission. 4) Provide solution/insights on technical issues from biologics developability assessment to CMC development. 5) Stay current with emerging trends, new technology POC aiming for cost effectiveness and/or improving operation excellence and efficiency. 6) Junior team members training and lab management. Qualification: 1) PhD in chemistry, chemical engineering, pharmaceutical sciences, biochemistry, biotechnology, bioengineering, or relevant field. 2) Proficient experimental skills, capable of independently completing study design, experiment execution, data collection and analysis, as well as report writing, and able to troubleshoot abnormal experimental results. 3) Familiar with antibody purification and ADC conjugation principles and operations, e.g., chromatography, UF/DF, stochastic conjugation and site-specific conjugation, etc. 4) High self-motivation to solve problems and explore state-of-the-art technologies. 5) Good English proficiency (reading/writing/speaking) for technical communication, documentation and cross-functional collaboration. 6) Ability to work independently, identify, and solve problems. Strong interpersonal skills with a good collaboration spirit. Result-driven with high agility in a changing environment. 7) Experience in applying AI tools to improve real work outcomes, with clear examples of impact (quality, speed, decision support) is a plus.